Your Cart


*Image for illustration purposes
  • Stock: 264
  • Model: PE-22-28
17 sold
5 or more £67.00
10 or more £65.00
25 or more £61.00
50 or more £48.00

PE-22-28 is a synthetic derivative of the naturally occurring peptide spading, which binds to TREK-1.

TREK-1 is found in regions of the brain controlling mood, memory, and learning.

Spadin is a secreted peptide derived from sortilin. It is an antagonist of the TREK-1 (TWIK-related-potassium channel) receptor, a two-pore potassium channel identified as a potential target in the treatment of depression and as a possible neurogenic regulator. Early studies in mice have shown that deleting the TREK-1 receptor makes them resistant to depression. Similarly, treatment with sortilin leads to resistance to depression and boosts the growth of both neurons and the synaptic interconnections between neurons.

Studies have suggested that blocking TREK-1 with spadin or its derivatives like PE-22-28 could help reduce depression-like symptoms in animal models.

Spadin has also been shown to promote neurogenesis and improve synaptic plasticity, which are essential processes in learning and memory.

PE-22-28 is being researched for applications including antidepressant activity, learning, stroke recovery and neurodegenerative diseases such as Alzheimer’s

Molecular Formula: C35H55N11O9

Sequence: GVSWGLR

Molecular Weight: 773.8947 g/mol

Write a review

All products listed and supplied by UK Peptides are strictly for research purposes only. We neither advocate nor support the personal usage of these products.

Products offered by UK Peptides are not intended for inclusion in food items or to be used as any form of medication. Our products are not designed to treat, prevent, lessen or cure any health condition or disease; they are solely for research purposes.

Please remember improper usage of these products can be harmful. Therefore, professionals must handle our products in a controlled environment for scientific research and study.