Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the meso diencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.
Delta sleep-inducing peptide was first discovered in 1974 by the Swiss Schoenenberger-Monnier group who isolated it from the cerebral venous blood of rabbits in an induced state of sleep. It was primarily believed to be involved in sleep regulation due to its apparent ability to induce slow-wave sleep in rabbits, but studies on the subject have been contradictory.
Delta-sleep-inducing peptide (DSIP)-like material has been found in human breast milk.
Its amino acid sequence is Тrр-Аlа-Gly-Gly-Asp-Ala-Ser-Gly-Glu.
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