ACE-031: Exploring the Frontier of Muscle Biology Research
ACE-031 is a recombinant fusion protein used in laboratory research on activin-receptor signalling. This page sets out what the molecule is, how it is characterised, and how it should be stored. It is written for laboratory use only.
What ACE-031 is
ACE-031 combines the extracellular domain of activin receptor type IIB (ActRIIB) with the Fc region of human IgG1. As a soluble form of the receptor it is used in vitro as a ligand trap: it binds ActRIIB ligands such as myostatin (GDF-8), activin A and GDF-11, which is why it appears in assays of TGF-beta superfamily signalling.
Identity and characterisation
- Type: ActRIIB-Fc fusion protein (glycoprotein dimer)
- Ligands bound in vitro: myostatin, activin A and B, GDF-11 and related ActRIIB ligands
- Supplied as: lyophilised solid, 1mg
- Purity: established by reverse-phase HPLC; identity by mass spectrometry
How it is used in the laboratory
Typical in-vitro applications are ligand-binding and receptor-competition assays, reporter-cell assays for SMAD2/3 signalling, and comparison with other ActRIIB ligand traps. Because ACE-031 binds several ligands rather than one, experimental design normally controls for which ligand is present.
Storage and stability
Store the sealed lyophilised vial at -20°C, protected from light and moisture. Once in solution, protein stability is limited and depends on buffer, temperature and freeze-thaw cycles, so single-use aliquots are the usual approach. Handling and all laboratory procedures are determined by the receiving laboratory under its own protocols.
Research use only
UK Peptides supplies ACE-031 strictly as a laboratory research material. It is not a medicine, and it is not for human or veterinary use. We do not provide preparation, handling or usage guidance, and we are unable to answer enquiries relating to human use.
Specification and availability: ACE-031 1mg product page.