5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR) is an intermediate in the generation of inosine monophosphate. AICAR is an analogue of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase (AMPK) activity. AICAR has been used clinically to treat and protect against cardiac ischemic injury. The drug was first used in the 1980s as a method to preserve blood flow to the heart during surgery. Currently, the drug has also been shown as a potential treatment for diabetes by increasing the metabolic activity of tissues by changing the physical composition of muscle.
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|Physical and chemical properties|
|Physical Appearance||White lyophilised solid|
|Peptide Sequence||5-Aminoimidazole-4-carboxamide ribonucleotide|
|Form & Formulations||Sterile filtered white lyophilized (freeze-dried)|
|Storage||Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18°C. Upon reconstitution of the peptide it should be stored at 4°C between 2-21 days and for future use below -18°C.|
|HPLC||Shows min 99% Purity|
|Mass Spectrum||Consistent with structure|
|Caution||Research use only / Not for human or veterinary use|
All products are sold for research purposes only
Not for human consumption